4ARK

Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1

RCSB Kinase

Target Species: Human
Kinase Family: STE7
Kinase Group: STE
Mutation: No

Resolution: 2.6
Release Year: 2013

Kinase Alias: PRKMK1, MKK1, MAP2K1, MAPKK1, MEK1
Downstream Molecules: ERK
Associated Diseases: Colorectal Cancer

Ligand ID: M3K

RCSB Ligand

Ligand Type: Type III Inhibitor
Binding Pocket: Hydrophobic pocket
Key Interaction Residues: Met146, Asp147, Gly148
Binding Data: IC50=63nM
Ligand SMILES: c1(ccc(cc1F)I)Nc1c(c(cc(c1)F)OCC[C@H](CO)O)C(=O)N
Reference: 10.1016/j.bmcl.2013.02.028