3W32

Epidermal growth factor receptor EGFR

RCSB Kinase

Target Species: Human
Kinase Family: EGFR
Kinase Group: TK
Mutation: No

Resolution: 1.8
Release Year: 2013

Kinase Alias: ERBB, ERBB1, EGFR, mENA, EGFRvIII
Downstream Molecules: JAK, Src, Shc
Associated Diseases: Cancer

Ligand ID: W32

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Gln791, Leu792, Met793
Binding Data: IC50=75nM
Ligand SMILES: c1cc(cc(c1)Oc1ccc(cc1Cl)Nc1c2c(ncn1)NCCC(=C2)C(=O)NCCS(=O)(=O)C)C(F)(F)F
Reference: 10.1016/j.bmc.2013.02.014