3VBX

Serine/threonine-protein kinase PIM1

RCSB Kinase

Target Species: Human
Kinase Family: PIM
Kinase Group: CAMK
Mutation: No

Resolution: 2.03
Release Year: 2012

Kinase Alias: PIM, PIM1
Downstream Molecules: MAP3K5, MYC
Associated Diseases: Acute Myeloid Leukemia, Breast Cancer

Ligand ID: 0FO

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Arg122, Pro123, Glu124
Binding Data: IC50=17uM
Ligand SMILES: C1C(=O)Oc2ccc(Br)cc2C1=O
Reference: 10.1021/jm2014698