3R00

Serine/threonine-protein kinase PIM1

RCSB Kinase

Target Species: Human
Kinase Family: PIM
Kinase Group: CAMK
Mutation: No

Resolution: 2.1
Release Year: 2011

Kinase Alias: PIM, PIM1
Downstream Molecules: MAP3K5, MYC
Associated Diseases: Acute Myeloid Leukemia, Breast Cancer

Ligand ID: UNJ

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu121, Arg122, Pro123
Binding Data: IC50=8.5uM
Ligand SMILES: c1(oc2c(c1)cc(cc2)Br)C(=O)O
Reference: 10.1016/j.bmcl.2011.03.030