3QQU

Insulin-like growth factor 1 receptor precursor IGF1R

RCSB Kinase

Target Species: Human
Kinase Family: InsR
Kinase Group: TK
Mutation: No

Resolution: 2.9
Release Year: 2011

Kinase Alias: MGC142172, IGF1R, MGC142170, IGFIR, CD221, MGC18216, JTK13
Downstream Molecules: GAB1, JAK, Src
Associated Diseases: Malignant Pleural Mesothelioma, Hepatocellular Carcinoma

Ligand ID: 01P

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Met1079, Leu1078, Glu1077
Binding Data: IC50=2.4nM
Ligand SMILES: c1cnc(nc1Nc1cc2ccccc2nc1)Nc1ccc(N2CCOCC2)c(OC)c1
Reference: 10.1016/j.bmcl.2011.02.075