3QGY

Tyrosine-protein kinase ITK/TSK

RCSB Kinase

Target Species: Human
Kinase Family: Tec
Kinase Group: TK
Mutation: No

Resolution: 2.1
Release Year: 2011

Kinase Alias: MGC126258, ITK, PSCTK2, MGC126258, EMT, LYK
Downstream Molecules: VAV, PLCG1
Associated Diseases: Other Well-Defined Immunodeficiency Syndromes, Lymphoproliferative Syndrome 1

Ligand ID: PQC

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu436, Ser437, Met438
Binding Data: Ki=16nM
Ligand SMILES: c1cc2c(c3c1sc(c3)c1ccccc1)nc(nc2)Nc1cc(ccc1)S(=O)(=O)N
Reference: 10.1021/jm101499u