3PRZ

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

RCSB Kinase

Target Species: Human
Kinase Family: PI3K/PI4K
Kinase Group: other
Mutation: No

Resolution: 2.6
Release Year: 2011

Kinase Alias: PIK3CG
Downstream Molecules: Akt, Itk
Associated Diseases: Breast Cancer, Myeloid Tumor

Ligand ID: 3RZ

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Asp884, Lys883, Val882
Binding Data: Ki=26nM
Ligand SMILES: Cc1nc(N)c2c(c(ccc2)C(=O)Nc2ccn[nH]2)n1
Reference: 10.1016/j.bmcl.2010.12.026