3PIY

Tyrosine-protein kinase BTK

RCSB Kinase

Target Species: Human
Kinase Family: TEC
Kinase Group: TK
Mutation: No

Resolution: 2.55
Release Year: 2011

Kinase Alias: AGMX1, IMD1, PSCTK1, BPK, ATK, XLA, MGC126261, MGC126262, AT, BTK
Downstream Molecules: PLCy
Associated Diseases: Chronic Lymphocytic Leukaemia; Rheumatoid Arthritis

Ligand ID: 585

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Met477, Tyr476, Glu475
Binding Data: IC50=0.29uM
Ligand SMILES: N1c2nc(Nc3nc(ncc3F)Nc3cc(c(c(c3)OC)OC)OC)ccc2OC(C1=O)(C)C
Reference: 10.1002/pro.575