3ORN

Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1

RCSB Kinase

Target Species: Human
Kinase Family: STE7
Kinase Group: STE
Mutation: No

Resolution: 2.8
Release Year: 2011

Kinase Alias: PRKMK1, MKK1, MAP2K1, MAPKK1, MEK1
Downstream Molecules: ERK
Associated Diseases: Colorectal Cancer

Ligand ID: 3OR

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ser209, Gly210, Val211
Binding Data: Kd=0.24nM
Ligand SMILES: c1(cc(CN2C(=O)CCCO2)c(F)c(c1Nc1ccc(cc1F)I)F)C(=O)NOCCO
Reference: 10.1016/j.bmcl.2011.01.062