3O51

Aurora A kinase AurA

RCSB Kinase

Target Species: Human
Kinase Family: Aur
Kinase Group: Other
Mutation: No

Resolution: 3.2
Release Year: 2010

Kinase Alias: MGC34538, BTAK, STK7, STK15, AURORA2, AURA, AIK, AurA, STK6, ARK1, AURKA
Downstream Molecules: CPEB
Associated Diseases: Acute Myeloid Leukemia, Advanced Solid Tumor

Ligand ID: LJF

RCSB Ligand

Ligand Type: Type II Inhibitor
Binding Pocket: ATP domain/Hydrophobic pocket
Key Interaction Residues: Glu211, Tyr212, Ala213
Binding Data: ~
Ligand SMILES: CNc1nc(c(cn1)F)c1cccnc1Oc1ccc(cc1)NC(=O)c1ccccc1Nc1ccccc1
Reference: 10.1021/jm100394y