3NUY

Phosphoinositide-dependent kinase-1 PDK1

RCSB Kinase

Target Species: Human
Kinase Family: PDK1
Kinase Group: AGC
Mutation: No

Resolution: 2.1
Release Year: 2011

Kinase Alias: MGC35290, PRO0461, PkB-like, PDK1, PkB-like 1, PDPK1, MGC20087
Downstream Molecules: AKT, SGK
Associated Diseases: Multiple Myeloma, Liver Tumor

Ligand ID: JPZ

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ala162, Tyr161, SER160
Binding Data: IC50=345uM
Ligand SMILES: c1ccc2c(c1)c(=O)[nH]cn2
Reference: 10.1021/ml100136n