3LXL

Tyrosine-protein kinase JAK3

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 1.74
Release Year: 2010

Kinase Alias: JAKL, LJAK, JAK3, L-JAK, JAK-3, JAK3_HUMAN
Downstream Molecules: STAT3, PI3K
Associated Diseases: Non-Small Cell Lung Cancer, T-Cell Acute Lymphoblastic Leikemia

Ligand ID: IZA

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Leu905, Tyr904, Glu903
Binding Data: IC50=5nM
Ligand SMILES: O=C1N=CCc2c3c(c4c(c12)cc(F)cc4)[nH]c(n3)C(C)(C)C
Reference: 10.1016/j.jmb.2010.05.020