3LQ5

Cyclin-dependent kinase 9 CDK9

RCSB Kinase

Target Species: Human
Kinase Family: CDK
Kinase Group: CMGC
Mutation: No

Resolution: 3
Release Year: 2011

Kinase Alias: CDC2L4, CDK9, PITALRE, C-2k, TAK
Downstream Molecules: GRIP1, Pirh2 protein
Associated Diseases: Lung Cancer, Pancreatic Cancer, Prostate Cancer

Ligand ID: SLQ

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu107, Cys106, Ser105
Binding Data: IC50=0.11uM
Ligand SMILES: n1c(N[C@@H](CC)CO)nc2c(c1NCc1ccc(c3ncccc3)cc1)ncn2C(C)C
Reference: 10.1177/1947601910369817