3LFC

Mitogen-activated protein kinase 14 MAPK14

RCSB Kinase

Target Species: Human
Kinase Family: MAPK
Kinase Group: CMGC
Mutation: No

Resolution: 2.8
Release Year: 2010

Kinase Alias: MAPK14, Exip, SAPK2a, CSBP1, Mxi2, CSBP2, P38, p38a, p38, PRKM14, EXIP, SAPK2A, RK, p38alpha, CSPB1, MXI2, PRKM15, p38ALPHA
Downstream Molecules: ELK1, P53, PRAK
Associated Diseases: Alzheimer Disease, Hepatocellular Carcinoma

Ligand ID: Z86

RCSB Ligand

Ligand Type: Type II Inhibitor
Binding Pocket: ATP domain/Hydrophobic pocket
Key Interaction Residues: Leu108, Met109, Gly110
Binding Data: Kd=287nM
Ligand SMILES: CC(C)(C)c1cc(NC(=O)Nc2nc(cs2)CCOCc2ccccc2)n(n1)c1ccc(cc1)CC(=O)O
Reference: ---