3IKA

Epidermal growth factor receptor EGFR

RCSB Kinase

Target Species: Human
Kinase Family: EGFR
Kinase Group: TK
Mutation: No

Resolution: 2.9
Release Year: 2010

Kinase Alias: ERBB, ERBB1, EGFR, mENA, EGFRvIII
Downstream Molecules: JAK, Src, Shc
Associated Diseases: Cancer

Ligand ID: 0UN

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Pro794, Met793, Leu792
Binding Data: IC50=14nM
Ligand SMILES: C1C[NH+](C)CCN1c1cc(OC)c(cc1)Nc1nc(c(cn1)Cl)Oc1cc(ccc1)NC(=O)CC
Reference: 10.1038/nature08622