3HUC

Mitogen-activated protein kinase 14 MAPK14

RCSB Kinase

Target Species: Human
Kinase Family: MAPK
Kinase Group: CMGC
Mutation: No

Resolution: 1.8
Release Year: 2010

Kinase Alias: MAPK14, Exip, SAPK2a, CSBP1, Mxi2, CSBP2, P38, p38a, p38, PRKM14, EXIP, SAPK2A, RK, p38alpha, CSPB1, MXI2, PRKM15, p38ALPHA
Downstream Molecules: ELK1, P53, PRAK
Associated Diseases: Alzheimer Disease, Hepatocellular Carcinoma

Ligand ID: G97

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Gly110, Met109, Leu108
Binding Data: Kd=1030nM
Ligand SMILES: c1ccccc1c1nc(c2c(n1)cc(NC(=O)C=C)cc2)Nc1ccn[nH]1
Reference: 10.1021/ja908083e