3F2A

Serine/threonine-protein kinase PIM1

RCSB Kinase

Target Species: Human
Kinase Family: PIM
Kinase Group: CAMK
Mutation: No

Resolution: 1.9
Release Year: 2009

Kinase Alias: PIM, PIM1
Downstream Molecules: MAP3K5, MYC
Associated Diseases: Acute Myeloid Leukemia, Breast Cancer

Ligand ID: 985

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu124, Pro123, Arg122
Binding Data: IC50=57nM
Ligand SMILES: c1(nc(cnc1)N1CC[N@H+](CCC1)C)c1cccc(c1)/C=C/C(=O)O
Reference: 10.1021/jm801242y