3E64

Tyrosine-protein kinase JAK2

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 1.8
Release Year: 2008

Kinase Alias: JAK2
Downstream Molecules: STAT3, PI3K
Associated Diseases: Polycythemia Vera, Myelofibrosis

Ligand ID: 5B3

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Leu932, Tyr931, Glu930
Binding Data: Kd=0.078uM
Ligand SMILES: O=S(=O)(NC(C)(C)C)c1ccc(cc1)c1cc2c(N)[nH]nc2cc1
Reference: 10.1016/j.bmcl.2008.08.064