3E63

Tyrosine-protein kinase JAK2

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 1.9
Release Year: 2008

Kinase Alias: JAK2
Downstream Molecules: STAT3, PI3K
Associated Diseases: Polycythemia Vera, Myelofibrosis

Ligand ID: 5B2

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Leu932, Tyr931, Glu930
Binding Data: IC50=1.6uM
Ligand SMILES: c12cc(ccc2[nH]nc1N)c1ccccc1
Reference: 10.1016/j.bmcl.2008.08.064