3BGZ

Serine/threonine-protein kinase PIM1

RCSB Kinase

Target Species: Human
Kinase Family: PIM
Kinase Group: CAMK
Mutation: No

Resolution: 2.4
Release Year: 2007

Kinase Alias: PIM, PIM1
Downstream Molecules: MAP3K5, MYC
Associated Diseases: Acute Myeloid Leukemia, Breast Cancer

Ligand ID: VX3

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu124, Pro123, Arg122
Binding Data: Ki=0.55uM
Ligand SMILES: O=C(O)c1c2[nH]c(c(c3ccccc3)c2ccc1)c1ccccc1
Reference: 10.1021/jm701248t