2XYN

Tyrosine-protein kinase ABL2

RCSB Kinase

Target Species: Human
Kinase Family: ABL
Kinase Group: TK
Mutation: No

Resolution: 2.81
Release Year: 2010

Kinase Alias: v-abl, c-ABL, JTK7, ABL, p150, ABL1, c-ab1
Downstream Molecules: p38-MAPK, JNK, JAK2, AKT, NTRK1
Associated Diseases: Dietary Shortage, Acute Myeloid Leukemia, B Lymphoblastic Leukemia/Lymphoma, Chronic Myeloid Leukemia (Cml)

Ligand ID: VX6

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Tyr363, Met364, Pro365
Binding Data: Kd=4nM
Ligand SMILES: [NH+]1(CCN(CC1)c1cc(nc(n1)Sc1ccc(cc1)NC(=O)C1CC1)Nc1cc(n[nH]1)C)C
Reference: 10.1021/jm101506n