2XIZ

Serine/threonine-protein kinase PIM1

RCSB Kinase

Target Species: Human
Kinase Family: PIM
Kinase Group: CAMK
Mutation: No

Resolution: 2.21
Release Year: 2011

Kinase Alias: PIM, PIM1
Downstream Molecules: MAP3K5, MYC
Associated Diseases: Acute Myeloid Leukemia, Breast Cancer

Ligand ID: XIZ

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu121, Arg122, Pro123
Binding Data: IC50=130uM
Ligand SMILES: C(=O)(O)/C=C/c1ccncc1
Reference: 10.1107/S0907444910054144