2VWZ

Ephrin type-B receptor 4 EPHB4

RCSB Kinase

Target Species: Human
Kinase Family: Eph
Kinase Group: TK
Mutation: No

Resolution: 1.65
Release Year: 2008

Kinase Alias: EPHB4, HTK, TYRO11, MYK1, EphB4
Downstream Molecules: Abl, RasGAP, Ephexin
Associated Diseases: Rhabdomyosarcoma, Chronic Myeloid Leukemia

Ligand ID: 7X6

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ser695, Met696, Glu697
Binding Data: IC50=0.794uM
Ligand SMILES: N(c1nccc(Nc2c3OCOc3ccc2Cl)n1)c1cccc(NS(=O)(=O)C)c1
Reference: 10.1016/j.bmcl.2008.09.087