2R3P

Cyclin dependent kinase 2 CDK2

RCSB Kinase

Target Species: Human
Kinase Family: CDK
Kinase Group: CMGC
Mutation: No

Resolution: 1.66
Release Year: 2008

Kinase Alias: p33(CDK2, p33(CDK2), CDK2, p33CDK2, P34cdk2
Downstream Molecules: SAMHD1, E2F-1, retinoblastoma protein
Associated Diseases: Colon Cancer, Prostate Cancer

Ligand ID: 3SC

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu81, Ser82, Leu83
Binding Data: IC50=900nM
Ligand SMILES: c1(c2n(nc1)c(cc(n2)c1c(c(ccc1)Cl)Cl)NCc1ccncc1)SC#N
Reference: 10.1002/bip.20868