2OW3

Glycogen synthase kinase-3 beta GSK3B

RCSB Kinase

Target Species: Human
Kinase Family: GSK
Kinase Group: CMGC
Mutation: No

Resolution: 2.8
Release Year: 2008

Kinase Alias: GSK3B
Downstream Molecules: TSC1, GLI1, GLI2, GLI3
Associated Diseases: Alzheimer Disease, Depressive Disorder, Melanoma

Ligand ID: BIM

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Asp133, Tyr134, Val135
Binding Data: IC50=3nM
Ligand SMILES: C1(=O)C2=C(C(=O)N1)c1c3ccccc3n(c1)CCCCc1ccc(CCCn3cc2c2c3cccc2)nc1N(C)C
Reference: 10.1016/j.bmcl.2007.02.059