2OIC

Interleukin-1 receptor-associated kinase 4 IRAK4

RCSB Kinase

Target Species: Human
Kinase Family: IRAK
Kinase Group: TKL
Mutation: No

Resolution: 2.4
Release Year: 2007

Kinase Alias: REN64, NY-REN-64, LOC51135, IRAK4
Downstream Molecules: TAK1, TAB
Associated Diseases: Pancreatic Ductal Adenocarcinoma, Inflammation, Oncology Disorders

Ligand ID: STU

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Val263, Tyr264, Met265
Binding Data: IC50=4nM
Ligand SMILES: O1[C@@H]2C[C@@H]([C@H]([C@@]1(C)n1c3c4c(c5c(c3c3c1cccc3)CNC5=O)c1c(cccc1)n24)OC)[NH2+]C
Reference: 10.4049/jimmunol.178.5.2641