2BRO

Serine/threonine-Transferase CHK1

RCSB Kinase

Target Species: Human
Kinase Family: CAMKL
Kinase Group: CAMK
Mutation: No

Resolution: 2.2
Release Year: 2005

Kinase Alias: CHEK1, CHK1, p56Chk1
Downstream Molecules: PLK1, BLM, Mad2
Associated Diseases: Gastric Cancer, Head And Neck Cancer, Pancreatic Cancer

Ligand ID: DF2

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu85, Tyr86, Cys87
Binding Data: IC50=1.4uM
Ligand SMILES: c1nc2c(c(NC[C@H](CO)O)n1)c(c(c1ccccc1)[nH]2)c1ccccc1
Reference: 10.1021/jm049022c