2BR1

Serine/threonine-Transferase CHK1

RCSB Kinase

Target Species: Human
Kinase Family: CAMKL
Kinase Group: CAMK
Mutation: No

Resolution: 2
Release Year: 2005

Kinase Alias: CHEK1, CHK1, p56Chk1
Downstream Molecules: PLK1, BLM, Mad2
Associated Diseases: Gastric Cancer, Head And Neck Cancer, Pancreatic Cancer

Ligand ID: PFP

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu85, Tyr86, Cys87
Binding Data: Ki=7.2uM
Ligand SMILES: COc1ccc(cc1)c1c2c(NCCO)ncnc2oc1c1ccc(OC)cc1
Reference: 10.1021/jm049022c