2BDF

Proto-oncogene tyrosine-protein kinase Src

RCSB Kinase

Target Species: Human
Kinase Family: Src
Kinase Group: TK
Mutation: No

Resolution: 2.1
Release Year: 2006

Kinase Alias: p60-Src, SRC, SRC1, ASV, c-SRC
Downstream Molecules: AFAP1, beta-catenin
Associated Diseases: Liver Cancer, Prostate Cancer

Ligand ID: 24A

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu339, Tyr340, Met341
Binding Data: IC50=0.067uM
Ligand SMILES: CCn1c2nc(nc(c2nc1)Nc1ccc(cc1)P(O)(O)CP(O)(O)O)[C@H]1CC[C@H]([NH3+])CC1
Reference: 10.1111/j.1747-0285.2005.00316.x