1Y6B

Vascular endothelial growth factor receptor 2 VEGFR2

RCSB Kinase

Target Species: Human
Kinase Family: VEGFR
Kinase Group: TK
Mutation: No

Resolution: 2.1
Release Year: 2005

Kinase Alias: FLK1, VEGFR, FLK-1, Hs.12337, VEGFR2, VEGFR-2, Hs.KDR, CD309, KDR
Downstream Molecules: PIK3R1, PLCG1
Associated Diseases: Colon Cancer, Osteosarcoma

Ligand ID: AAX

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu915, Ser916, Cys917
Binding Data: IC50=38nM
Ligand SMILES: O=S(=O)(NCC1CC1)c1ccc(c(c1)Nc1oc(cn1)c1cc(ccc1)c1cnccc1)OC
Reference: 10.1021/jm049538w