1X8B

Wee1-like protein kinase WEE1

RCSB Kinase

Target Species: Human
Kinase Family: WEE
Kinase Group: Other
Mutation: No

Resolution: 1.81
Release Year: 2005

Kinase Alias: FLJ16446, Wee1, WEE1, DKFZp686I18166, WEE1hu
Downstream Molecules: CDK1
Associated Diseases: Ovarian Cancer, Lung Cancer

Ligand ID: 824

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu377, Tyr378, Cys379
Binding Data: IC50=97nM
Ligand SMILES: O=C1C=Cc2c(C1)c1c([nH]2)cc(c2c1c(=O)[nH]c2=O)c1ccccc1
Reference: 10.1016/j.str.2004.12.017