1E9H

Cyclin dependent kinase 2 CDK2

RCSB Kinase

Target Species: Human
Kinase Family: CDK
Kinase Group: CMGC
Mutation: No

Resolution: 2.5
Release Year: 2001

Kinase Alias: p33(CDK2, p33(CDK2), CDK2, p33CDK2, P34cdk2
Downstream Molecules: SAMHD1, E2F-1, retinoblastoma protein
Associated Diseases: Colon Cancer, Prostate Cancer

Ligand ID: INR

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu81, Ser82, Leu83
Binding Data: IC50=35nM
Ligand SMILES: c12c(cccc1)C(=O)/C(=C/1\C(=O)Nc3c1cc(cc3)S(O)(O)O)/N2
Reference: 10.1016/s0969-2126(01)00598-6