Synergists

Index Name RScore ZScore
1 Acetylcholinesterase 40801(313,635,1025,4151) 33.29
2 cholinesterase 29730(218,486,796,2700) 24.2
3 cytochrome P450 (protein family or complex) 24846(187,400,609,2451) 20.19
4 catalase 17796(109,262,497,3311) 14.41
5 ATPase 17668(130,268,410,2418) 14.3
6 cytochrome c 12675(75,224,370,1475) 10.2
7 NMDA receptor (protein family or complex) 11723(83,214,232,1063) 9.42
8 caspase 3 10505(86,168,203,990) 8.42
9 albumin 9822(70,135,266,1617) 7.86
10 glutathione S transferase 9577(58,139,331,1547) 7.66
11 P glycoprotein 8761(71,131,203,921) 6.99
12 superoxide dismutase 8676(40,125,325,1926) 6.92
13 hemoglobin (protein family or complex) 8141(50,110,274,1521) 6.48
14 p38 8027(67,124,139,882) 6.39
15 lactate dehydrogenase (protein family or complex) 6608(47,99,183,868) 5.23
16 chloride channel (protein family or complex) 5998(42,111,125,498) 4.72
17 alcohol dehydrogenase (protein family or complex) 5845(45,96,133,530) 4.6
18 acetylcholine receptor (protein family or complex) 5821(51,88,125,446) 4.58
19 sodium channel (protein family or complex) 5671(46,70,146,891) 4.46
20 CS2 5567(23,72,221,1512) 4.37
21 C18 5452(30,58,248,1262) 4.28
22 alkaline phosphatase 5455(31,78,209,910) 4.28
23 bcl 2 5277(36,78,129,882) 4.13
24 CYP3A4 4834(38,77,104,489) 3.77
25 estrogen receptor 4769(39,69,99,599) 3.72
26 caspase (protein family or complex) 4572(28,81,100,647) 3.55
27 transferase 4401(26,73,124,656) 3.41
28 NADH dehydrogenase 4346(32,74,112,336) 3.37
29 CYP2B6 4225(36,66,94,305) 3.27
30 calmodulin 4211(22,78,113,596) 3.26
31 androgen receptor 4129(34,70,83,264) 3.19
32 mitogen activated protein kinase (protein family or complex) 4026(30,61,71,646) 3.11
33 IL 6 3946(27,59,89,676) 3.04
34 vascular endothelial growth factor 3870(31,53,78,605) 2.98
35 tumor necrosis factor alpha 3655(19,65,97,595) 2.8
36 CYP1A1 3604(27,52,99,459) 2.76
37 demethylase 3557(24,58,113,342) 2.72
38 CYP3A 3377(25,52,77,442) 2.57
39 GABA receptor (protein family or complex) 3360(26,57,69,290) 2.56
40 AP 1 (protein family or complex) 3303(25,55,67,343) 2.51
41 IgE 3246(20,44,63,831) 2.47
42 peroxisome proliferator activated receptor 3241(24,44,55,666) 2.46
43 ATPases 3190(30,44,70,240) 2.42
44 protein kinase C (protein family or complex) 3177(19,53,65,577) 2.41
45 c jun 3181(30,45,65,231) 2.41
46 xanthine oxidase 3155(21,54,80,355) 2.39
47 alpha synuclein 3120(20,46,117,385) 2.36
48 CYP1A2 3101(23,51,66,346) 2.35
49 Lipoxygenase (protein family or complex) 2945(14,58,78,405) 2.22
50 lysozyme 2919(22,39,76,464) 2.2
51 brains 2891(14,51,103,401) 2.18
52 angiotensin II 2828(18,37,49,758) 2.12
53 lipase 2718(20,40,67,383) 2.03
54 Cl 2 2542(17,39,71,362) 1.89
55 CYP2E1 2532(19,38,53,367) 1.88
56 glutathione reductase 2513(14,41,85,363) 1.86
57 thrombin 2396(21,32,38,356) 1.77
58 protein is 2368(15,32,56,538) 1.75
59 monoamine oxidase 2361(19,38,53,196) 1.74
60 5 HT 2A 2354(17,40,41,299) 1.73
61 calcineurin (protein family or complex) 2340(18,38,41,285) 1.72
62 carbonic anhydrase 2233(18,37,41,203) 1.64
63 interferon gamma 2230(18,33,48,265) 1.63
64 Tyrosinase 2232(16,35,43,342) 1.63
65 complex is 2127(12,39,53,287) 1.55
66 CYP2C19 1975(17,31,45,125) 1.42
67 adenylyl cyclase 1953(14,30,46,273) 1.41
68 myeloperoxidase 1919(14,29,41,289) 1.38
69 IL 1beta 1746(14,23,41,266) 1.24
70 sulfotransferase 1723(8,38,41,168) 1.22
71 beta glucuronidase 1698(13,22,31,343) 1.2
72 NADH:ubiquinone oxidoreductase (protein family or complex) 1648(11,28,43,183) 1.15
73 beta glucosidase 1636(14,25,34,141) 1.15
74 cytochrome P450 monooxygenases 1601(13,26,32,141) 1.12
75 alanine aminotransferase 1577(6,20,60,477) 1.1
76 PI3K 1531(11,23,28,266) 1.06
77 CD4 1522(7,19,46,467) 1.05
78 Telomerase (protein family or complex) 1496(14,20,29,151) 1.03
79 epidermal growth factor receptor 1419(13,19,25,169) 0.97
80 aspartate aminotransferase 1421(5,22,50,371) 0.97
81 glutathione transferase 1381(9,24,36,151) 0.94
82 CD34 1386(5,7,56,681) 0.94
83 CYP2B 1349(8,23,46,144) 0.91
84 SRBC 1342(13,19,27,82) 0.9
85 phospholipase A2 1320(10,24,24,100) 0.89
86 Fatty acid amide hydrolase 1315(7,27,29,145) 0.88
87 casein 1292(5,19,64,247) 0.86
88 Pr 3 1272(10,21,24,127) 0.85
89 malate dehydrogenase 1236(10,17,31,156) 0.82
90 thioredoxin 1236(8,19,26,231) 0.82
91 caspase 9 1209(8,22,26,129) 0.79
92 phosphatidylinositol 3 kinase (protein family or complex) 1195(8,21,24,150) 0.78
93 fibronectin 1182(6,17,24,337) 0.77
94 c Myc 1166(8,17,35,166) 0.76
95 PPAR gamma 1131(8,15,25,231) 0.73
96 glucagon 1116(9,15,24,171) 0.72
97 metallothionein (protein family or complex) 1066(6,9,38,351) 0.68
98 interleukin (protein family or complex) 1032(6,18,24,162) 0.65
99 ICAM 1 1033(7,15,24,188) 0.65
100 IL 10 1025(7,14,20,225) 0.64
101 Ah receptor 1024(7,16,20,174) 0.64
102 beta catenin 947(8,10,20,197) 0.58
103 glyceraldehyde 3 phosphate dehydrogenase 928(8,12,15,153) 0.56
104 uroporphyrinogen decarboxylase 883(7,11,27,123) 0.53
105 cis 3 856(7,14,17,71) 0.5
106 MP2 839(4,14,23,174) 0.49
107 CB1 receptor 827(6,15,20,52) 0.48
108 Microsomal monooxygenase 814(7,13,18,49) 0.47
109 aldehyde oxidase 806(4,15,22,121) 0.46
110 P450scc 789(8,11,12,54) 0.45
111 Myosin 776(6,9,13,186) 0.44
112 CD8 768(3,7,26,313) 0.43
113 glucose 6 phosphatase 724(5,12,21,69) 0.4
114 annexin V 733(4,10,27,148) 0.4
115 glucose 6 phosphate dehydrogenase 720(2,12,34,150) 0.39
116 microsomal monooxygenases 712(6,12,15,37) 0.39
117 epoxide hydrolase 690(2,11,32,155) 0.37
118 yl 1 676(2,17,22,41) 0.36
119 erythropoietin 668(4,6,23,203) 0.35
120 thioredoxin reductase 640(5,8,19,95) 0.33
121 matrix metalloproteinase 2 633(5,11,12,48) 0.32
122 glutamyl transpeptidase 610(2,8,33,145) 0.3
123 glycolytic enzymes 609(5,9,13,69) 0.3
124 aryl hydrocarbon hydroxylase 597(3,11,24,52) 0.29
125 ferrochelatase 581(3,10,20,81) 0.28
126 protein as 559(2,11,18,94) 0.26
127 glial fibrillary acidic protein 525(3,6,19,130) 0.23
128 cytochrome P450 1A1 505(4,7,12,70) 0.22
129 prion protein 504(4,6,15,79) 0.22
130 ceruloplasmin 507(4,6,13,92) 0.22
131 extracellular signal regulated kinase 1 491(2,11,13,51) 0.21
132 Toll like receptor 4 491(4,5,9,121) 0.21
133 PK1 487(2,9,12,102) 0.2
134 proton pump 487(1,13,13,47) 0.2
135 histone deacetylase (protein family or complex) 479(1,10,12,119) 0.2
136 CREB 461(3,8,10,61) 0.18
137 peroxisome proliferator activated receptor alpha 420(3,6,6,90) 0.15
138 CYP2C8 425(3,8,10,25) 0.15
139 5 HT 1A 411(1,10,11,56) 0.14
140 CYP3A5 406(4,5,8,41) 0.14
141 human ether a go go related gene 385(3,6,10,35) 0.12
142 caspase 1 388(4,5,5,38) 0.12
143 HDAC 372(2,5,12,87) 0.11
144 cytochrome b5 342(2,5,10,67) 0.08
145 calpain (protein family or complex) 336(3,4,4,66) 0.08
146 Hepatocyte growth factor 322(2,4,6,92) 0.07
147 STAT5 313(2,6,6,33) 0.06
148 ERK2 314(2,6,6,34) 0.06
149 NHE1 297(3,4,4,27) 0.05
150 SBP1 303(2,6,7,18) 0.05
151 Salvador 296(1,4,16,66) 0.05
152 P19 301(2,5,6,46) 0.05
153 cis 2 286(1,6,12,26) 0.04
154 PCl 3 284(3,4,5,9) 0.04
155 RAGE 279(1,5,11,49) 0.03
156 G protein coupled receptors 251(2,3,4,56) 0.01
157 glutamine transaminase K 254(3,3,3,14) 0.01
158 lecithin:cholesterol acyltransferase 227(2,3,4,32) -0.01
159 PCNA 223(0,4,6,93) -0.01
160 glial cell line derived neurotrophic factor 232(1,4,9,37) -0.01
161 HGPRT 234(2,3,8,19) -0.01
162 Sulfite Oxidase 212(1,4,6,32) -0.02
163 PdCl 2 222(2,3,4,27) -0.02
164 VEGFR 2 220(2,3,3,30) -0.02
165 TGFbeta 202(2,2,3,37) -0.03
166 interleukin 4 209(1,2,5,84) -0.03
167 cytochrome P450 reductase 188(1,4,4,18) -0.04
168 apolipoprotein 183(1,2,7,48) -0.05
169 Ki 67 178(1,1,5,78) -0.05
170 gelatinases 181(2,2,2,21) -0.05
171 FMO3 172(1,3,6,17) -0.06
172 cytokeratin 168(0,2,11,63) -0.06
173 connexin 32 168(2,2,3,3) -0.06
174 methionine R sulfoxide reductases 166(1,3,3,26) -0.06
175 FRAP 163(0,3,3,73) -0.06
176 glutaredoxin 162(0,3,6,57) -0.06
177 CD44 163(1,2,3,48) -0.06
178 tryptophan hydroxylase 153(0,4,5,28) -0.07
179 survivin 158(0,3,5,58) -0.07
180 beta lactoglobulin 152(0,2,10,52) -0.07
181 acylase 155(1,3,3,15) -0.07
182 FMO1 140(1,1,6,35) -0.08
183 hES 138(1,2,3,23) -0.08
184 HER2 143(0,2,4,73) -0.08
185 Thymosin beta 4 134(0,4,4,14) -0.09
186 MSRA 135(0,1,2,100) -0.09
187 G6PD 127(0,1,9,57) -0.09
188 DGAT 128(1,2,3,13) -0.09
189 CB2 124(1,2,2,14) -0.1
190 gamma secretase (protein family or complex) 120(0,3,4,25) -0.1
191 retinoid X receptor alpha 107(0,2,3,42) -0.11
192 CAPE 103(0,1,4,58) -0.11
193 RAPTOR 108(0,3,4,13) -0.11
194 F11 103(0,0,15,28) -0.11
195 PARP 1 96(0,2,3,31) -0.12
196 transferrin receptor 98(0,1,4,53) -0.12
197 CD14 91(0,2,2,31) -0.12
198 PTEN 96(0,1,2,61) -0.12
199 cholecystokinin 89(0,2,3,24) -0.12
200 MT 1 90(1,1,2,5) -0.12
201 CYP1B1 90(0,2,4,20) -0.12
202 factor A 88(0,2,2,28) -0.13
203 TLR2 77(0,2,2,17) -0.13
204 serotonin 5 HT 2C receptor 82(1,1,1,2) -0.13
205 LysoPLA 85(1,1,1,5) -0.13
206 bFGF 67(0,0,1,62) -0.14
207 PPAR delta 75(0,1,3,35) -0.14
208 fatty acid synthase 70(0,0,0,70) -0.14
209 ADAMTS 13 54(0,1,1,24) -0.15
210 CT 1 62(0,2,2,2) -0.15
211 von Willebrand factor 52(0,1,1,22) -0.15
212 thymosin beta 10 63(0,2,2,3) -0.15
213 enolase 53(0,1,1,23) -0.15
214 paraoxonase 1 43(0,0,0,43) -0.16
215 glucosylceramide synthase 40(0,1,2,5) -0.16
216 methionine sulfoxide reductase B 44(0,0,1,39) -0.16
217 TCPT 38(0,1,1,8) -0.17
218 oct 6 31(0,1,1,1) -0.17
219 CuL 2 35(0,1,1,5) -0.17
220 CA4 35(0,1,1,5) -0.17
221 PTPE 31(0,1,1,1) -0.17
222 TESS 30(0,0,4,10) -0.17
223 WAF1 35(0,0,0,35) -0.17
224 apoA I 27(0,0,0,27) -0.18
225 PLGF 20(0,0,1,15) -0.18
226 beta3Gn T8 5(0,0,0,5) -0.19
227 neuromedin U 5(0,0,0,5) -0.19
228 COX2 8(0,0,0,8) -0.19
229 vasopressin V2 receptor 6(0,0,0,6) -0.19
230 Dax 1 9(0,0,0,9) -0.19
231 SACS 9(0,0,1,4) -0.19
232 CD62P 15(0,0,0,15) -0.19
233 PPIA 5(0,0,0,5) -0.19
234 1 Cys 7(0,0,0,7) -0.19
235 E5NT 10(0,0,0,10) -0.19
236 LIPA 6(0,0,0,6) -0.19
237 CXCL8 12(0,0,0,12) -0.19
238 ENTPD1 6(0,0,0,6) -0.19
239 NRSF 6(0,0,0,6) -0.19
240 cyclin L2 8(0,0,0,8) -0.19
241 orexin 1 receptors 6(0,0,0,6) -0.19
242 INSL3 6(0,0,0,6) -0.19
243 Notch1 11(0,0,0,11) -0.19
244 insulin like growth factor binding protein 4 8(0,0,0,8) -0.19
245 AR7 5(0,0,0,5) -0.19
246 NPYR 7(0,0,0,7) -0.19
247 GATA 4 15(0,0,0,15) -0.19
248 signal transducer and activator of transcription 6 9(0,0,0,9) -0.19
249 pim 1 11(0,0,0,11) -0.19
250 mitogen activated protein kinase phosphatase 3 10(0,0,0,10) -0.19
251 Death associated protein 5 8(0,0,0,8) -0.19
252 mGluR4 7(0,0,0,7) -0.19
253 CK 8 10(0,0,1,5) -0.19
254 coagulation factor VIII 2(0,0,0,2) -0.2
255 activating transcription factor 3 2(0,0,0,2) -0.2
256 enolases (protein family or complex) 2(0,0,0,2) -0.2